We Love It's Guide to…
As Ann searches a neon megacity for her missing brother, explore in 3D and fight through 2D arenas with weapons and upgrades.
Released 16 Mar 2022
Explore Neon Districts
Fight In 2D Arenas
Track Your Missing Brother
ANNO: Mutationem is an action-adventure game with RPG elements set in a cyberpunk world, featuring a unique mix of pixelated 2D & 3D graphic style with a rich, dark and bizarre plot.
Developed by ThinkingStars · Published by ThinkingStars









You play as Ann Flores, a combat-trained woman searching a sprawling cyberpunk metropolis for her missing brother, with hacker Ayane as her partner. The investigation takes them through city districts and other locations, where they question residents, follow leads, and take on missions.
Gameplay shifts between 3D exploration and 2D side-scrolling sections focused on platforming and combat. Ann fights with melee weapons and firearms, using combos and other abilities against enemies and bosses.
Collect, buy, and craft items to improve Ann’s stats, skills, and equipment. Weapon chips let you adjust weapons, while side quests, conversations, and activities such as bartending and minigames offer diversions from the main investigation.
Players who enjoyed the game often highlight its detailed pixel-art characters against 3D environments, neon cyberpunk atmosphere, and engaging exploration. Combat is described by some as satisfying and lively, though others find it repetitive or awkward. Opinions on the story vary, with several reviewers finding it confusing or uneven.
Welcome to the neon-covered, 2D-meets-3D Cyberpunk world of ANNO: Mutationem. In this Action-Adventure game with RPG elements you become Ann: a highly-skilled combat-trained lone wolf on a personal mission in the giant Metropolis, full of sinister mega-corporations, mysterious fringe groups and creatures more bizarre than words can express.
This is a world full of surprises waiting for you to find out! While going thru the main story you can chat with a Cyborg corgi, take on a part-time bartender job, hunt down vicious criminals reveal the true face of a trending V-streamer! By exploring diverse locations such as neon Noctis Town, an off-shore cargo ship and huge underground structures, players are free to go as they please and act as they want.
Unique 2D-to-3D gameplay, seamless switching between 2D Action n' Platforming and 3D Exploration to interact with the world and its inhabitants. Let's dive into pixel gaming from another perspective!
Ann will slash, shoot, combo, grenade-throw & ground-pound her way through hordes of enemies and huge bosses. From great swords to double blades, from pistols to rocket launchers and uppercuts, time to become the one-girl army you always knew you had in you.
A grand story, befitting a rich and dark cyberpunk décor, featuring our main hero Ann Flores and her trusty hyper hacker side-kick Ayane on a personal mission to find out where her missing brother has gone to. Little do the two know just what they will unravel…
Collect, buy or craft items & upgrade Ann's stats, skills and gear. Use chips to modify any kind of weapon you find. Equip Ann and make her combat-ready for all enemies (both humanoid and not…) that are about to head her way.

| Platforms | Windows, macOS |
|---|---|
| Achievements | 36 |
| Age ratings |
|
| Controller support | PlayStation, Xbox |
| Controller required | No |
| Demo | View demo on Steam |
| DLC / extras | 2 listed on Steam |
| Website | Official website |