We Love It's Guide to…
Evolve a pathogen from Patient Zero, spreading it across the globe while adapting to border closures and humanity’s cure efforts.
Released 18 Feb 2016
Mutate Before Detection
Race the Cure
Infect Island Nations
Plague Inc: Evolved is a unique mix of high strategy and terrifyingly realistic simulation. Your pathogen has just infected 'Patient Zero' - now you must bring about the end of human history by evolving a deadly, global Plague whilst adapting against everything humanity can do to defend itself.
Developed by Ndemic Creations · Published by Ndemic Creations









You guide a disease from its first infection toward a global outbreak. Choose where it begins, then shape how it spreads and how dangerous it becomes as countries respond.
Earn DNA points as infection and deaths grow, and spend them on transmission routes, symptoms, and abilities such as environmental or drug resistance. Balance stealth and lethality: early detection can speed cure research, while killing too quickly can leave people uninfected.
Different disease types and scenarios change the challenges and strategies available. The game also includes competitive and cooperative multiplayer, a scenario editor for creating and sharing custom outbreaks, and a cure mode in which you manage responses to an outbreak.
Players who enjoy the game often praise the strategy of choosing when to spread quietly, evolve traits, and respond to humanity’s countermeasures, along with experimenting across disease types and scenarios. Some find this loop absorbing and atmospheric; others say runs become repetitive or depend too much on luck, so the appeal of replaying varies.

Plague Inc: Evolved is a unique mix of high strategy and terrifyingly realistic simulation. Your pathogen has just infected 'Patient Zero' - now you must bring about the end of human history by evolving a deadly, global Plague whilst adapting against everything humanity can do to defend itself.
Plague Inc. is so realistic that the CDC even asked the developer to come and speak about the infection models in the game!
“The game creates a compelling world that engages the public on serious public health topics.”
- Ali S. Khan, CDC
Over 190 million players have been infected by Plague Inc. already. Now, Plague Inc: Evolved combines the original critically acclaimed gameplay with significant, all-new features for PC including multiplayer, user-generated content support, improved graphics and lots more.

10 Different Disease Types – Master every pathogen; from bacteria to bio-weapons and mind control to zombies, end humanity by any means possible – different diseases will need radically different approaches.
23 Unique Scenarios – Adapt your strategy; scenarios create further challenges for your pandemic – how will you handle a new strain of Swine Flu, or infect a world in Ice Age?
Hyper-Realistic World – Strategize in the real world; advanced AI and use of real-world data and events make Plague Inc: Evolved a highly authentic simulation of a world-ending pathogen. Even the CDC likes it!
Competitive Multiplayer - The world is unlucky enough to be infected with two plagues, but how will you win the battle for genetic dominance against your opponent? Players get all new evolutions, abilities and genes to help them fight for global control and destroy their opponent!
Co-Operative Mode - Two different diseases team up to infect and destroy the world together but Humanity has new tricks up its sleeve to fight back! Work closely with your partner and use brand-new genes, traits and strategies to smash cure labs all over the world before they eradicate you.
Contagious Content Creator - Hit the lab and develop your own custom scenarios - creating new plague types, worlds and in-game events. Sophisticated tools support user-generated content to let players bring their deadliest ideas to life and share them on Steam Workshop. With over 10,000 custom scenarios already released - there is always something new to infect!
Blinding Graphics - Full 3D disease models take you closer to your plague than ever before, city-cams show humanity's struggle at street level, and the body scanner highlights the full effect of your mutations, organ by organ.
Deadly Data - Geek out with stats and graphs; monitor infection and death levels, track government reactions and cure efforts, then review your plague's success (or failure!) with full game replays.
And much more... - Including speed runs, Mega-Brutal difficulty and genetic modification... Plus loads of new disease types and scenarios in future (free!) updates.
| Platforms | Windows, macOS, Linux |
|---|---|
| Achievements | 250 |
| Age ratings |
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| Players | 1–2 |
| Play modes |
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| Other modes |
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| Multiplayer | Plague Inc: Evolved supports both single-player and online multiplayer. Multiplayer consists of competitive versus and co-operative play, with two players either competing as separate plagues or working together against humanity. Steam lists Online PvP and Online Co-op, and the descriptions repeatedly state play with an opponent or partner. |
| Multiplayer & mods | The game has Steam Workshop and a scenario creator with user-generated content. The provided text confirms custom scenarios and mods exist, but does not clearly confirm whether these can be used in multiplayer. |
| Controller support | Xbox |
| Controller required | No |
| DLC / extras | 3 listed on Steam |
| Content notices |
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| Website | Official website |