We Love It's Guide to…
Defend a microscopic arena as a turret, combining DNA-based weapons and run upgrades to survive waves of hostile microbes.
Released 07 May 2024
Combine DNA Weapons
Defend Against Microbes
Build Perk Combos
COMBINE WEAPONS in the microscopic roguelite turret shooter with macroscopic depth. Survive 6 modes using an astounding array of turrets, perks, mutations and power-ups on this psychedelic journey to the heart of the abyss. Shmup Mode turns it into a vertical shoot 'em up!
Developed by Alpherior · Published by Alpherior









You control a defensive turret in a microscopic world, aiming and firing at waves of hostile microbes. Runs take place across several modes and increasing depths, with a vertical shoot-'em-up mode offering a different format.
Weapons come from combining four DNA bases, each associated with a different firing style, to create hybrid bioweapons. You can further shape your build with turrets, weapon mods, perks, and mutations that affect the run.
Between runs, research permanent upgrades and unlock more options. Runs are designed to last around 20 minutes, and can continue in Endless Mode; the six modes and multiple depths offer different challenges.
Many supplied reviewers enjoy experimenting with DNA weapon combinations and customizing builds, and often point to the steady stream of unlocks and replay value as reasons to keep playing. The soundtrack and colorful visuals also receive praise. Some reviewers, however, find runs repetitive or the screen difficult to read during busy combat.
Dive into the microscopic world, radiating with bioluminescent life and unspeakable horrors. Genome Guardian is a deeply-complex shooter that's easy to pick up but hard to master. Research permanent upgrades to survive a variety of microbes across 6 game modes, each with multiple "depths".
Pair DNA nucleotides Adenine (rapidfire), Cytosine (precision), Guanine (spread), Thymine (explosive) to discover wild hybrid bioweapons!
Bomb + Shotgun combines explosives with spread to create Blast Shotgun!
Bomb + Bomb doubles down on explosive power to make Bazooka!
Blast Shotgun + Shotgun forms the all-powerful Flak Cannon!

49 Turrets with unique strengths and functions
96 Perks to mix and match that drastically change how you play
75 Weapon & Turret Mods that can turn shots into sticky laser mines or bouncing fireballs
64 Mutations alter the challenges you face each run

20-minute Runs that can be continued in Endless Mode
75 Bassy Electronic Tunes that adapt to the current mood & intensity
Cosmetics like spider legs and tank tread
Accessibility Settings for colourblindness, motion sickness, and even arachnophobia!
100 Steam Achievements
Steam Trading Cards
Cloud Save
Plays great on Steam Deck!!!

| Platforms | Windows |
|---|---|
| Achievements | 100 |
| Age ratings |
|
| Controller support | PlayStation, Xbox |
| Controller required | No |
| Demo | View demo on Steam |
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