Games Like Pathogenic

Pathogenic

You are a disease. Infect the human body as a lone pathogen in this cellular roguelike shooter. Collect organelles to evolve your parasite in a microscopic arms race against your host's immune system. Conquer a beautiful, procedurally generated world of tiny proportions.

★ TINY ROGUES ★ HAND OF FATE: HORDES ★ ATOMINE ★ NUCLEAR THRONE ★ DUNHERO ★ CLUCKMECH OASIS ★ BLAZING BEAKS ★ GATEKEEPER: INFINITY ★ TELEGLITCH: DIE MORE EDITION ★ DARK FAIRY TALE: DREAMLAND SURVIVORS ★ DISFIGURE ★ GENOME GUARDIAN ★ WE ♥ IT 
1

Tiny Rogues

96% 👍 OF 10K
About This Game

Tiny Rogues is a challenging fantasy rogue-lite bullet-hell dungeon crawler with rpg elements. Build a new unique character each run and fight one monster-infested room after another! Discover unique weapons, collect magical items and level up to become more and more powerful!

Player reviews say you can…

  • …dash into the center, go intangible, and trigger a nuke on skill use that wipes the room without firing your weapon.
  • …dash so fast you're throwing area-of-effect knives 7–8 times a second, and stack permanent doubled booze buffs until everything shreds on contact.
  • …turn into a moving crit turret where every shot crits, triggers extra attacks, and keeps doubling its own damage loop.
4

Nuclear Throne

96% 👍 OF 19K
About This Game

Nuclear Throne is a post-apocalyptic roguelike-like top-down shooter. Not 'the final hope of humanity' post-apocalyptic, but 'humanity is extinct and mutants and monsters now roam the world' post-apocalyptic. Can you reach the Nuclear Throne?

Player reviews say you can…

  • …beat the throne, destroy the side generators, and trigger a hidden surprise that changes what comes after that fight.
  • …survive a fatal hit and keep fighting for a few seconds as a headless chicken.
  • …pull enemies toward you while pushing bullets away with telekinesis.
6

Cluckmech Oasis

88% 👍 OF 3.6K
About This Game

Cluckmech Oasis, a top-down shooting Roguelike tower defense game. Play as the Warcluck and lead your team of animal heroes in a fight for survival. Collect, build and upgrade defenses, and engage in intense battle against waves of plant enemies.

Player reviews say you can…

  • …Choose a Base Site
  • …Shoot for Resources
  • …Place Defenses Anywhere
7

Blazing Beaks

83% 👍 OF 2.6K
About This Game

Roguelite - where too much greediness can be fatal. A colorful world with armed birds blazing their way through piles of mutants, monsters and creepy creatures. Lots of mysteries to unravel, secrets to discover and levels to explore.

Player reviews say you can…

  • …Carry Cursed Artifacts
  • …Trade Curses for Loot
  • …Team Up in Story Mode
8

Gatekeeper: Infinity

92% 👍 OF 4.4K
About This Game

Prologue version of the game Gatekeeper. Gatekeeper: Infinity is a fast-paced rogue-lite shooter where you'll search for the stolen Heart of the Universe and battle machine enemies! Play solo or join forces with friends in co-op mode.

Player reviews say you can…

  • …Recover the Heart
  • …Battle Machine Enemies
  • …Try Four Characters
REL Nov 10, 2023 FREE ON STEAM See This Game →
9

Teleglitch: Die More Edition

85% 👍 OF 2.9K
About This Game

In a cold, dark future dominated by mega-corporations, a small lonely planet on the edge of habitable space is the site of a shadowy research facility specializing in necrotic tissue reactivation. You are a scientist who has suddenly awoken to the realization that you are the lone survivor.

Player reviews say you can…

  • …Craft Weapons From Scrap
  • …Scavenge Scarce Ammo
  • …Explore Changing Maps
10

Dark Fairy Tale: Dreamland Survivors

89% 👍 OF 591
About This Game

This is a top-down, auto-shooting roguelike that can be played entirely one-handed. Players take on the role of Pinocchio, fallen into a nightmare, collecting forbidden Dream Eggs that grant ever-changing offensive and survival abilities. Slay twisted fairy tale creatures in endless nightmares!

Player reviews say you can…

  • …Devour Dream Eggs
  • …Reorder Three Weapons
  • …Flip Tarot Boss Cards
11

Disfigure

98% 👍 OF 7.5K
About This Game

Disfigure is a grim-dark action rogue-like where you battle relentless hordes of monsters lurking in the shadows. Unlock powerful weapons, craft god-like builds with hundreds of upgrades, slay colossal bosses, and push your limits in intense 20–30 minute survival runs!

Player reviews say you can…

  • …swap your vision between a tight circle and a long cone, and fight while everything outside it stays pitch-black.
  • …widen that vision cone, add a second cone behind you, or slow enemies just for being in your line of sight.
  • …stack radiation with faster firing until every few shots blast everything you can currently see.
12

Genome Guardian

92% 👍 OF 785
About This Game

COMBINE WEAPONS in the microscopic roguelite turret shooter with macroscopic depth. Survive 6 modes using an astounding array of turrets, perks, mutations and power-ups on this psychedelic journey to the heart of the abyss. Shmup Mode turns it into a vertical shoot 'em up!

Player reviews say you can…

  • …Combine DNA Weapons
  • …Defend Against Microbes
  • …Build Perk Combos