The Medical Sim Zone

Simulations of healthcare, diagnosis, surgery, hospitals, or medical decision-making.

See the best Medical Sim games See the free Medical Sim games Do a power search within Medical Sim games

Recent releases that landed well, newest first, filtered to games with enough reviews to trust the score.

Smile More - A short medical simulation horror game with multiple endings where the imperfect are made HAPPY. Perform tasks and operations on sedated patients to fix their defects before submitting your files to the Ministry of Happiness & Peace!

Mar 13, 2026

95% 👍

of 341

Free on Steam More Detail

Angel Engine - Cage an angel. Ransack Heaven. In a far-flung dystopian future, the Angel Engine Initiative carries on as the last hope for humanity. Seal yourself in your operating room, perform surgery on comatose test subjects, and pray you make it out alive.

Mar 6, 2026

80% 👍

of 347

Survival Horror · Resource Management · Time Management · Quick-Time Events · Psychological Horror · Puzzle · Horror · Difficult · First-Person · Simulation · Medical Sim · Story Rich · 3D · Point & Click · Jump Scare

$7.99 on Steam More Detail

Do No Harm - Players say: Run a village clinic on a haunted island: diagnose patients, dose ancient remedies, spot anomalies, and face choices over 30 days. Players like: Lovecraftian Atmosphere · Medical Casework · Distinctive Art Style ·

Read More ▶Less ◀

Lovecraftian Doctor Simulator. Diagnose patients by analyzing unsettling symptoms and treat them using your Book of Medicine. Make moral choices — decide who to save or kill, discover whom to trust, and unlock multiple endings! Can you endure 30 days of perilous decisions?

Mar 6, 2025

75% 👍

of 950

Lovecraftian · Medical Sim · Story Rich · Choices Matter · Time Management · Investigation · Mystery · Psychological Horror · Multiple Endings · First-Person · Dark · Replay Value · Lore-Rich · Point & Click · Puzzle

$15.99 on Steam More Detail

Herbals tycoon - "Herbals tycoon" is a game that combines ancient style with deep management strategy, bringing players into a mysterious and fantastic world of traditional Chinese medicine. Here, you are not only a healer but also an explorer, manager, and inheritor, writing your own herbal legend every moment.

Jan 16, 2025

79% 👍

of 158

Early Access · Simulation · RPG · Life Sim · Sandbox · Medical Sim · Exploration · Time Management · Story Rich · Multiple Endings · Colorful · 2D · CRPG · Isometric · Medieval

$9.99 on Steam More Detail

Potion Tycoon - Players say: Run a magic potion shop: source ingredients, refine recipes, automate brewing, manage staff, and compete for customers. Players like: Engaging Shop Management · Charming Visual Style · Potion Recipe Crafting ·

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Potion Tycoon is a management simulator with a witchy twist! Build and develop your very own magic shop. Manage resources, set up production lines, mix potions and sell them smartly to stay ahead of the competition. Welcome to the potion business!

Oct 4, 2024

72% 👍

of 731

Management · Simulation · Building · Sandbox · Shop Keeper · Strategy · Magic · Economy · Automation · Resource Management · Capitalism · 2D · Fantasy · Singleplayer · Medieval

$19.99 on Steam More Detail

Revenge Of The Colon - Revenge of the colon is a story driven, single-player, atmospheric, body horror game with multiple endings. Perform colonoscopies on five patients and discover the horrors concealed deep within them. PS1 horror style!

Dec 22, 2023

85% 👍

of 421

Horror · Atmospheric · Surreal · Psychological Horror · Psychological · Supernatural · Story Rich · Singleplayer · Walking Simulator · Choices Matter · Retro · Dark Humor · Multiple Endings · Old School · Casual

$12.99 on Steam More Detail

Oyabu Clinic Deathcare Corporation - Alchemy with patients' lives and health insurance! A quack doctor simulation game. DON'T imitate any of this!

Sep 1, 2023

94% 👍

of 239

Medical Sim · Dark Comedy · Turn-Based Tactics · JRPG · RPG · Horror · Management · 2D · Cyberpunk · Funny · Story Rich · Dark Humor · Turn-Based Combat · Multiple Endings · Simulation

$14.99 on Steam More Detail

Discounted 25% or more right now, limited to well-reviewed games, steepest cuts first.

Two Point Hospital - Players say: Build and run hospitals across Two Point County, diagnosing bizarre illnesses, training staff, and meeting each site's goals. Players like: Absurd Illnesses · Satisfying Hospital Management · Theme Hospital Nostalgia ·

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Design stunning hospitals, cure peculiar illnesses and manage troublesome staff as you spread your budding healthcare organisation across Two Point County.

Aug 29, 2018

92% 👍

of 35k

Simulation · Management · Medical Sim · Building · Funny · Singleplayer · Strategy · Sandbox · Indie · Comedy · Casual · City Builder · Cartoony · Replay Value · Multiplayer

$29.99 -75% $7.49 on Steam More Detail

Big Pharma - Players say: Run a drug company by researching ingredients, tuning medicines, fitting production lines, and competing in a shifting market. Players like: Factory Layout Puzzles · Production Optimization · Business Strategy Mix ·

Read More ▶Less ◀

What if you had it in your power to rid the world of disease, to improve the lives of millions, to ease suffering and cure the sick… and earn a tidy profit? As the head of your own Pharmaceutical Conglomerate you have this power resting in your hands. Will you use it for good?

Aug 27, 2015

77% 👍

of 1.9k

Management · Simulation · Medical Sim · Strategy · Automation · Indie · Puzzle · Economy · Singleplayer · Isometric · Resource Management · Casual · Base Building · 2D · Sandbox

$24.99 -75% $6.24 on Steam More Detail

Well-liked but under-played: strong scores, small review counts.

Heart's Medicine - Hospital Heat - The long awaited sequel to "Heart's Medicine - Time to Heal". An intense, but also funny, medical drama that deals with a lot of life-changing decisions. Become an aspiring doctor at Little Creek Hospital!

May 23, 2017

96% 👍

of 366

Casual · Simulation · Adventure · Indie · Medical Sim · Time Management · Story Rich · Female Protagonist · Great Soundtrack · 2D · Singleplayer

$19.99 on Steam More Detail

Heart's Medicine - Time to Heal - Players say: As aspiring surgeon Allison Heart, manage Little Creek Hospital’s patient rush with quick treatment tasks while following a medical drama. Players like: Brisk Patient Rush · Emotional Hospital Drama · Treatment Minigames ·

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An intense, but also funny, medical drama that deals with a lot of life-changing decisions. Become an aspiring surgeon at Little Creek Hospital!

Sep 20, 2016

94% 👍

of 884

Casual · Medical Sim · Indie · Simulation · Time Management · Adventure · Female Protagonist · Singleplayer · Story Rich · 2D

$19.99 on Steam More Detail

Weed Shop 2 - Players say: Turn a rundown California dispensary into a thriving shop by growing cannabis, serving customers, hiring staff, and expanding. Players like: Rewarding Progression · Funny Simulator ·

Read More ▶Less ◀

Weed Shop 2 is a first person recreational Marijuana dispensary simulator where you'll get to grow the hottest strains, expand your business, hire employees and much more!

Mar 30, 2017

86% 👍

of 905

FPS · Life Sim · Immersive Sim · Management · Open World · Building · Crime · Medical Sim · Sandbox · Farming Sim · Strategy · First-Person · Funny · Relaxing · Surreal

$9.99 on Steam More Detail

Plague M.D. - Plague M.D. is a medieval medicine simulator. Become a quack doctor stuck in a backwater village in the 16th century.

Nov 10, 2020

75% 👍

of 160

Indie · Simulation · Funny · Singleplayer · Adventure · Casual · Point & Click · Hand-drawn · Puzzle · Atmospheric · 2D · Replay Value · Difficult · Comedy · Medieval

$5.99 -20% $4.79 on Steam More Detail

Defining examples of the genre, all rated 85%+ across 1,000+ reviews.

Project Hospital - Players say: Build and run a hospital, staffing departments and guiding patients through examinations, diagnoses, treatments, and surgery. Players like: Realistic Medical Detail · Hands-On Diagnosis · Flexible Hospital Design ·

Read More ▶Less ◀

Become an ace doctor, an aspiring architect and a successful manager at the same time. Design your very own hospital, tweak every detail or choose one of the prebuilt scenarios and just jump to the doctor’s duty.

Oct 30, 2018

89% 👍

of 9.3k

Management · Medical Sim · City Builder · Job Simulator · Simulation · Sandbox · Strategy · Building · Education · Economy · Life Sim · Character Customization · Realistic · 2D · Isometric

$24.99 on Steam More Detail

Bio Inc. Redemption - Players say: Manage a patient's health from either side: diagnose and treat diseases, or build illness chains before doctors can intervene. Players like: Two-Sided Campaigns · Diagnostic Deduction · Strategic Case Variety ·

Read More ▶Less ◀

Bio Inc.: Redemption is a realistic simulation and strategy game in which you make life or death decisions. Create a deadly illness to infect and torment your victim or play as the head of a medical team and hopefully find a cure to save your human patient. Will you be the plague or preserve humanity?