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S.E.M.I. – Side Effects May Include... View on Steam

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S.E.M.I. – Side Effects May Include...

S.E.M.I. is a single-player and co-op action platformer with puzzle elements. Play as patients of an unusual clinic, take experimental drugs, interfere with each other, and be ready for chaos and unpredictable side effects! Players gave S.E.M.I. – Side Effects May Include... a 86% positive score. Released January 23, 2026. Top tags include Co-op, Platformer, Physics, Multiplayer, Online Co-Op, Surreal, Third Person, Character Customization, Psychological, and Indie.

S.E.M.I. is a single-player and co-op action platformer with puzzle elements.

Released 23 Jan 2026

86%positive of
113 player reviews
$7.99
View on Steam

S.E.M.I. is a single-player and co-op action platformer with puzzle elements. Play as patients of an unusual clinic, take experimental drugs, interfere with each other, and be ready for chaos and unpredictable side effects!

Developed by Two Horn Unicorn · Published by Two Horn Unicorn

S.E.M.I. – Side Effects May Include... screenshot 1S.E.M.I. – Side Effects May Include... screenshot 2S.E.M.I. – Side Effects May Include... screenshot 3S.E.M.I. – Side Effects May Include... screenshot 4S.E.M.I. – Side Effects May Include... screenshot 5S.E.M.I. – Side Effects May Include... screenshot 6S.E.M.I. – Side Effects May Include... screenshot 7S.E.M.I. – Side Effects May Include... screenshot 8S.E.M.I. – Side Effects May Include... screenshot 9

S.E.M.I. – Side Effects May Include... has about 97 positive and 16 negative player reviews out of a total 113. We'll add a detailed breakdown here when there are more reviews.

86%
positive of 113 player reviews

Back of the Box

Platforms Windows
Achievements 9
Age ratings
  • ClassInd (Brazil) 14 — Nudez Violência fantasiosa
  • IGRS (Indonesia) 18 — Interaksi Daring Kekerasan
  • Steam (Germany) 12 — Fantasy-Gewalt
Controller support Xbox
Controller required No
DLC / extras 3 listed on Steam
Content notices
  • In-game chat, Online interactivity

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Is S.E.M.I. – Side Effects May Include... free?▾
S.E.M.I. – Side Effects May Include... is currently listed at $7.99. Get it on Steam here.
Who made S.E.M.I. – Side Effects May Include..., and when did it come out?▾
It was developed by Two Horn Unicorn and published by Two Horn Unicorn, released on January 23, 2026.
What should I play if I like S.E.M.I. – Side Effects May Include...?▾