Best Outbreak Sim Games on Steam

Simulations of spreading disease, containment, collapse, infection, or emergency response.

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1Plague Inc: Evolved - Plague Inc: Evolved is a unique mix of high strategy and terrifyingly realistic simulation. Your pathogen has just infected 'Patient Zero' - now you must bring about the end of human history by evolving a deadly, global Plague whilst adapting against everything humanity can do to defend itself.
In this game, you can…
  • mutate your disease into zombies, vampires, or mind-controlled slaves that play by totally different rules.
  • play as a health team fighting the outbreak, choosing quarantines, treatment priorities, and vaccine logistics as deaths keep rising.
  • make countries bomb each other as outbreak events escalate, even in multiplayer.
  • stay undetected in a country, keep it non-lethal, then flip to a killer strain that wipes everyone out in days.
  • start an outbreak that triggers quarantined hospitals, travel warnings, curfews, and mass isolation orders as the situation escalates in real time.
  • manipulate infected people with a mind-worm, or trigger a full zombie apocalypse that overruns the world.
  • hold back lethality until the whole world is infected, then unleash fatal symptoms so fast the cure can't finish in time.
  • play multiplayer where two plagues fight for genetic dominance with evolutions built to counter each other's strategies.
  • build custom scenarios and download thousands of community-made outbreaks with unique rules and event chains.
2No, I'm not a Human - WARNING. Stay inside. Lock your doors. Close the blinds. Only let humans in. Eliminate all Visitors. An anxiety horror about paranoia in the End of Times.
In this game, you can…
  • drink kombucha to save your game, treating each jar like a scarce resource.
  • pet, feed, and even use your cat strategically to prevent a murder.
  • watch a knock at the door turn into a murder the same night someone arrives.
  • decide who gets shelter when strangers knock at your door at night.
  • examine eyes, hands, teeth, nails, and other body parts to spot Visitor signs, knowing no single clue is reliable.
  • interrogate guests, catch contradictions in their stories, and decide whether they're human before your house gets too crowded.
  • order groceries and cat food by phone, then wait for a delivery worker to bring it through the wasteland to your door.
  • get forced into a seat-by-seat shuffle when a newcomer wants someone else's spot: kick one out, refuse the new arrival, or make room and deal with it.
360 Seconds! Reatomized - The post-apocalyptic dark comedy is back - remastered and even more radioactive than before! Scavenge supplies, rescue your family, and stay alive in your fallout shelter. Make difficult decisions, hunt mutant roaches... and maybe survive. Or not.
In this game, you can…
  • open the shelter door to strangers, then watch them "clean out the trash" by taking your food, water, and even your son.
  • deal with bunker events where a giant spider moves in and pays rent while you decide how to respond.
  • sprint through your house for 60 seconds, grabbing supplies and family members, then slam the shelter door right before the nuke hits.
  • choose between saving a family member or stuffing your last slot with soup, a gas mask, or a flashlight.
  • send a family member into the wasteland, then have them return with supplies, return injured, or come back green.
  • try to befriend a giant cockroach while mutant roaches and other radioactive creatures infest your shelter.
  • survive long enough for a military rescue, even if the rest of your family dies along the way.
4Politics The Game - Become a parliamentarian, create a powerful party, and lead it to victory in this humorous adventure game. Manage your popularity and dignity, use unique powers, and navigate a storyline inspired by current events.
In this game, you can…
  • bury opponents under a mountain of stinking manure, blast a shockwave with the Speaker's Staff, or trigger bizarre mustached-man incantations as political weapons.
  • build your own political party as a newly elected Polish MP, climbing the polls while keeping your dignity high enough to stay in the game.
  • hit a finale that turns the political satire into a full-on rap battle showdown.
  • fight parliamentary battles where popularity and dignity are the stakes, and each turn is about outwitting opponents instead of trading normal attacks.
  • call in weird allies mid-crisis, from "support from above" after a Wadowice treat to New Year's Eve power you can use year-round.
  • scour hidden corners for collectibles, then get payoffs from odd item descriptions and dialogue that turn the text itself into the joke.
  • take on puzzles and mini-games, including piano sections that can be genuinely challenging.
  • visit extra locations and continue the story in two free expansions with new areas.
5ICBM - ICBM is a real-time strategy game of nuclear destruction. Research new technologies, build up your nuclear stockpile and use a combination of ships, planes and missiles to strike at the heart of your opponents’ cities while keeping your population safe from harm.
In this game, you can…
  • pack a nuke with decoys, so one launch turns into a deception game that overwhelms missile defenses.
  • launch submarine nukes from unexpected places, including dozens of MIRVs hidden somewhere in the ocean.
  • build a city-defense web strong enough that a major city can survive a nuclear hit with most of its population still alive.
  • specialize in a tech path, build layered missile defenses, then launch a timed first strike with silos, trucks, and nuclear subs.
  • pre-plan strikes on specific structures, units, and cities, then synchronize launches so multiple ICBMs hit at once.
  • use spy satellites and shared radar through alliances to spot enemy launch sites and coordinate attacks around that intel.
  • let stealth bombers with huge nuclear payloads erase regional defenses fast, while your airbase network also fields enough fighters to swat raids.
  • set a full war plan for air, naval, space, and missile forces, hit execute, and watch the whole timed assault unfold on the globe.
6Shadows of Forbidden Gods - Take on the role of a Dark Elder God and lead your agents to bring about an apocalypse in a fantasy world. Work in the shadows, avoiding the heroes who will try to stop you, as you bring about plague and famine, ice age and volcanic destruction, madness and never ending night.
In this game, you can…
  • drive a heroic savior insane, then use them to cast the final ritual that lets your god touch every mind and break the world.
  • cast a spell that multiplies one undead army into 8–10 ghoul armies, then have them cross the ocean and wipe out uncorrupted settlements.
  • pretend to be a harvest goddess, offer a "miracle cure" during a pandemic, and use the addiction to enshadow the leadership of multiple kingdoms.
  • infect people with a mind-controlling fungus until the entire world becomes a single hive mind that worships you.
  • burst forth as a Godzilla-sized snake monster as an end-of-the-world option.
  • get the prophesied Chosen One randomly picked from your own corrupted madmen, then help collapse an alliance into civil war under an insane leader.
  • stage a plague so a city cracks down on its own citizens, then let the fallout drive a distant king into violent, irrational wars.
  • kill a soul-eating creature in the middle of a sea battle, then curse the hero's entire family so a ruler elsewhere starts hearing a damned spirit howl.
7Execute - Kill everyone in the world with a guillotine… on a cursed Win98 desktop.
In this game, you can…
  • build the nuke setup, send workers to produce nukes, then watch the whole system turn into a supply chain for wiping out the planet.
  • scale the guillotine up to absurd sizes while your numbers climb into the billions of executions.
  • reach an ending where your own robots leave you for last, and you press the button to have them kill you.
  • start with a guillotine, then unlock mines, machines, and nukes for bigger and bigger execution methods.
  • capture someone, throw them in jail, bring them out, then execute them to fund upgrades that speed up the whole process.
  • turn manual killing into an automated pipeline, with each old step getting mechanized while you keep adding new machines to manage.
  • hit a final stretch where you mostly hold one button to keep the endgame killing apparatus running until extinction is complete.
8The Fabulous Fear Machine - The Fabulous Fear Machine is a narrative-driven strategy game with a pulp horror style. As the Machine's new Master, you must sow fear and expand your influence by creating Legends, harvesting resources, manipulating events, and spying on your enemies.
In this game, you can…
  • gaslight whole regions into banning useful pharmaceuticals, then steer everyone toward your own flawed products.
  • feed coins and fear into a wish-granting machine, watch people get what they want, and then trigger ironic punishments that can spiral into mass doom.
  • watch the same legend mutate into different forms depending on the city, including turning into much gorier outcomes in some places.
  • play urban-legend cards that plant fear in a city, mutate the place, and snowball until the media reacts and the legend gets stronger.
  • send a tiny team of agents to explore towns, infiltrate enemies, and make risky calls while you juggle too many urgent jobs at once.
  • start with simple scares like black helicopters or snakes in toilets, then twist something wholesome into a nightmare like turning perfect waters into a chemical dumping ground.
  • reveal a horror story through comic-book pages that unlock in fragments as you complete objectives across the map.
  • counter "good" rival groups that actively undo your fear campaigns, forcing you to sabotage and redirect their attempts to reverse your influence.
9Happy's Humble Burger Farm Alpha - Your dream is about to become a reality as you just landed a brand new job at the latest iteration of the Happy's Humble fast food franchises, Happy's Humble Burger Farm, a little taster in this first ALPHA 1.
In this game, you can…
  • crawl into the sewers to escape the shift loop and reach a hidden ending beneath the burger joint.
  • rack up three mistakes and trigger the mascot cow to start hunting you around the restaurant.
  • scavenge for collectible music CDs around town and play them in your apartment or at the restaurant.
  • run a full fast-food shift solo: take orders, cook burgers, fry sides, fill drinks, bag meals, and race the timer.
  • drive to work at night, open the restaurant, survive the shift, then close up and repeat the routine as the world gets stranger.
  • get hit with surreal chaos events in the kitchen, like a container glitching out and spawning cheese everywhere.
  • explore beyond the kitchen by roaming the city at night to find secrets, hidden areas, and odd encounters.
10Baby Blues Nightmares - Toddler Horror Game - Baby Blues Nightmares is a survival horror stealth game where you play as a toddler going into a little adventure with your tricycle which you can fix, maintain and customize. Paddle, hide and survive but remember; try not to cry when you are scared.. or the monsters will hear you and get you.
In this game, you can…
  • keep your happiness up by eating sweets so you don't cry and give away your location.
  • ride a tricycle through a nightmare playschool while a demon-like parent patrols for you.
  • drag a stool to a door, climb drawers to the counter, and slip into tiny hiding spots to survive.
  • blink at the wrong time and feel your heart rate spike as the game weaponizes something automatic.
  • nap in safe spots to save, then crawl back out into the maze of tubes, lockers, and play structures.
  • fix, maintain, and customize your tricycle, then stash your favorite toys on it as you roam.
  • scribble crayon drawings on walls that double as clues to piece together what happened.
  • replay to find different escape outcomes by taking different routes through the semi-open maps.